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研究業績


Publications (2008~) [ ]以外、すべて当研究室オリジナルの原著&総説

(2020)

1. Sugiyama A, Kaisho M, Okada M, Otani K, and Yamawaki H. Decreased expression of canstatin in rat model of monocrotaline-induced pulmonary arterial hypertension: protective effect of canstatin on right ventricular remodeling. Int J Mol Sci 21: 6797, 2020.

2. Sugiyama A, Ito R, Okada M, and Yamawaki H. Long-term administration of recombinant canstatin prevents adverse cardiac remodeling after myocardial infarction. Sci Rep 10: 12881, 2020.

3. Kodama T, Okada M, and Yamawaki H. Eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood pressure in spontaneously hypertensive rats via inducing vasorelaxation. J Pharmacol Sci 144: 165-171, 2020.

4. Yamamoto A, Matsumoto K, Hori K, Kameshima S, Yamaguchi N, Okada S, Okada M, and Yamawaki H. Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain. Pflugers Archiv - Eur J Physiol 472: 673-681, 2020.

5. Fujioka Y, Otani K, Okada M, and Yamawaki H. Plasma small extracellular vesicles in hypertensive rats impair reactivity of isolated blood vessels. J Vet Med Sci 82: 897-902, 2020.

6. Imoto K, Aratani M, Koyama T, Okada M, and Yamawaki H. Thrombospondin-4 induces prolongation of action potential duration in rat isolated ventricular myocytes. J Vet Med Sci 82: 707-712, 2020.

7. Omori A, Goshima M, Kakuda C, Kodama T, Otani K, Okada M, and Yamawaki H. Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats. Pflugers Archiv - Eur J Physiol 472: 335-342, 2020.

8. Otani K, Yokoya M, Fujioka Y, Okada M, and Yamawaki H. Small extracellular vesicles from rat plasma promote migration and proliferation of vascular smooth muscle cells. J Vet Med Sci 82: 299-306, 2020.

9. Sugiyama A, Okada M, and Yamawaki H. Canstatin suppresses isoproterenol-induced cardiac hypertrophy through inhibition of calcineurin/nuclear factor of activated T-cells pathway in rats. Eur J Pharmacol 871: 172849, 2020.

[10]. Abugomaa A, Elbadawy M, Yamanaka M, Goto Y, Hayashi K, Mori T, Uchide T, Azakami D, Fukushima R, Yoshida T, Shibutani M, Yamashita R, Kobayashi M, Yamawaki H, Shinohara Y, Kaneda M, Usui T, and Sasaki K. Establlishment of 2.5 organoid culture model using 3D bladder cancer organoid culture. Sci Rep 10: 9393, 2020.

[11]. Elbadawy M, Abugomaa A, Yamawaki H, Usui T, and Sasaki K. Development of prostate cancer organoid culture midels in basic medicine and translational research. (Review) Cancers 12: 777, 2020.

[12]. Elbadawy M, Yamanaka M, Goto Y, Hayashi K, Tsunedomi R, Hazama S, Nagano H, Yoshida T, Shibutani M, Ichikawa R, Nakahara J, Omatsu T, Mizutani T, Katayama Y, Shinohara Y, Abugomaa A,  Kaneda M, Yamawaki H, Usui T, and Sasaki K. Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model. Biomaterials 237: 119823, 2020.

[13]. Abugomaa A, Elbadawy M, Yamawaki H, Usui T, and Sasaki K. Emerging roles of cancer stem cells in bladder cancer progression, tumorigenesis, and resistance to chemotherapy: A potential therapeutic target for bladder cancer. (Review) Cells 19: 235, 2020.


(2019)

1. Otani K, Fujioka Y, Okada M, and Yamawaki H. Optimal isolation method of small extracellular vesicles from rat plasmaInt J Mol Sci 20: 4780, 2019.

2. Kodama T
, Okada M, and Yamawaki H. Eukaryotic elongation factor 2 kinase inhibitor, A484954 potentiates β-adrenergic receptor agonist-induced acute decrease in diastolic blood pressure in rats. J Vet Med Sci 81: 1509-1514, 2019.

3. Sugiyama A*
, Mitsui A*, Okada M, and Yamawaki H. Cathepsin S degradates arresten and canstatin in infarcted area after myocardial infarction in rats. J Vet Med Sci 81: 522-531, 2019. *: Co-first authors.

4. Kameshima S, Okada M, and Yamawaki H. Eukaryotic elongation factor 2 (eEF2) kinase/eEF2  plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts.  Apoptosis 24: 359-368, 2019.

5. Yasuda J, Okada M, and Yamawaki H. Protective effect of T3 peptide, an active fragment of tumstatin, against ischemia/reperfusion injury in rat heart. J Pharmacol Sci 139: 193-200, 2019.

6. Imoto K, Okada M, and Yamawaki H. Periostin mediates right ventricular failure through induction of inducible nitric oxide synthase expression in right ventricular fibroblasts from monocrotaline-induced pulmonary arterial hypertensive rats Int J Mol Sci 20: 62, 2019.

7. Kodama T, Okada M, and Yamawaki H. Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits noradrenaline-induced acute increase of blood pressure in rats. J Vet Med Sci 81: 35-41, 2019.

8. Okada M and Yamawaki H.  A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain. (Review) J Pharmacol Sci 139: 59-64, 2019.

[9].
Elbadawy M, Usui T, Mori T, Tsunedomi R, Hazama S, Nabeta R, Uchide T, Fukushima R, Yoshida T, Shibutani M, Tanaka T, Masuda S, Okada R, Ichikawa R, Omatsu T, Mizutani T, Katayama Y,  Noguchi S, Iwai S, Nakagawa T, Shinohara Y, Kaneda M, Yamawaki H, and Sasaki K. Establishment of a novel experimental model for muscle-invasive bladder cancer by using dog bladder cancer organoid culture. Cancer Sci 110: 2806-2821, 2019.

[10].
Elbadawy M, Usui T, Yamawaki H, and Sasaki K. Emerging roles of c-Myc in cancer stem cell-related signaling and resistance to cancer chemotherapy: a potential therapeutic target against colorectal cancer. (Review) Int J Mol Sci 20: 2340, 2019.


(2018)

1. Otani K, Yokoya M, Kodama T, Hori K, Matsumoto K, Okada M, and Yamawaki H. Plasma exosomes regulate systemic blood pressure in rats. Biochem Biophys Res Commun 503: 776-783, 2018.

2. Imoto K
, Okada M, and Yamawaki H. Characterization of fibroblasts from hypertrophied right ventricle of pulmonary hypertensive rats. Pflugers Archiv - Eur J Physiol 470: 1405-1417, 2018.

3. Kodama T, Okada M, and Yamawaki H. Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery. J Pharmacol Sci 137: 86-92, 2018.

4. Imoto K*, Hirakawa M*, Okada M, and Yamawaki H. Canstatin modulates L-type calcium channel activity in rat ventricular cardiomyocyte. Biochem Biophys Res Commun 499: 954-959, 2018. *: Co-first authors.

5. Sugiyama A, Hirano Y, Okada M, and Yamawaki H. Endostatin stimulates proliferation and migration of myofibroblasts isolated from myocardial infarction model rats. Int J Mol Sci 19: 741, 2018.

6. Yamawaki H. A novel regulatory mechanism for differetiation of mesencymal stem cell: Redox state of DJ-1 matters. (Commentary) Proteomics 18: 1700345, 2018.

7. Okada M and Yamawaki H.  Basement membrane-derived matricryptins as a new target molecule for heart failure treatment. (Review)
Folia Pharmacol Jpn 151: 106-110, 2018.

8. Okada M.  Extracellular matrix biomarkers for cardiac diseases. Folia Pharmacol Jpn 152: 208, 2018.

9. Okada M. Regulation of adventitial fibroblast functions in pulmonary hypertension. Folia Pharmacol Jpn 152: 258, 2018.

[10]
Elbadawy M, Usui T, Yamawaki H, and Sasaki K. Novel functions of death-associated protein kinases through mitogen-activated protein kinase-related signals. (Review) Int J Mol Sci 19: 3031, 2018.

[11] Elbadawy M, Usui T, Yamawaki H, and Sasaki K. Development of an experimental model for analyzing drug resistance in colorectal cancer. (Review) Cancers 10: 164, 2018.

[12] Usui T, Sakurai M, Umata K, Elbadawy M, Ohama T, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato K, Kaneda M, and Sasaki K. Hedgehog signals mediate anti-cancer drug resistance in three-dimensional primary colorectal cancer organoid culture. Int J Mol Sci 19: 1098, 2018.

[13]
Usui T, Sakurai M, Umata K, Yamawaki H, Ohama T, and Sato K. Preparation of human primary colon tissue-derived organoid using air liquid interface culture. Curr Protoc Toxicol 75: 22.6.1-22.6.7, 2018.


(2017)

1. Yasuda J, Fukui K, Okada M, and Yamawaki H. T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway. Naunyn Schmiedebergs Arch  Pharmacol 390: 1135-1144, 2017.

2.
Sakamoto Y*, Kameshima S*, Kakuda C, Okamura Y, Kodama T, Okada M, and Yamawaki H. Visceral adipose tissue-derived serine protease inhibitor prevents the development of monocrotaline-induced pulmonary arterial hypertension in rats. Pflugers Archiv - Eur J Physiol 469: 1425-1432, 2017. *: Co-first authors.

3. Okada M, Imoto K, Sugiyama A, Yasuda J, and Yamawaki H. (Review) New insights into the role of bsaement membrane-derived matricryptins in heart. Biol Pharm Bull 40: 2050-2060, 2017.

4. Otani K, Okada M, and Yamwaki H. Diverse distribution of tyrosine receptor kinase B isoforms in rat multiple tissues. J Vet Med Sci 79: 1516-1523, 2017.

5. Yasuda J, Okada M, and Yamawaki H. T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts. Eur J Pharmacol 807: 64-70, 2017.

6. Imoto K, Okada M, and Yamawaki H. Expression profile of matricellular proteins in hypertrophied right ventricle of monocrotaline-induced pulmonary hypertensive rats. J Vet Med Sci 79: 1096-1102, 2017.

7. Sugiyama
A, Okada M, and Yamawaki H. Pathophysiological roles of canstatin on myofibroblasts after myocardial infarction in rats. Eur J Pharmacol 807: 32-43, 2017.

8. Okamura Y*, Otani K*, Sekiguchi A, Kogane T, Kakuda C, Sakamoto Y, Kodama T, Okada M, and Yamawaki H. Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 4.
Pflugers Archiv - Eur J Physiol 469: 1177-1188, 2017. *: Co-first authors.

9.
Kanazawa H*, Imoto K*, Okada M, and Yamawaki H. Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts. PLOS ONE e0173051, 2017. *: Co-first authors.

10.
Okada M, Murata N and Yamawaki H. Canstatin stimulates migration of rat cardiac fibroblasts via secretion of matrix metalloproteinase-2. Am J Physiol-Cell Physiol 312: C199-C208, 2017.

11. Kazama K*, Hoshino K*, Kodama T, Okada M, and Yamawaki H. Adipocytokine, progranulin augments acetylcholine-induced nitrix oxide-mediated relaxation through the increases of cGMP production in rat isolated mesenteric artery. Acta Physiol (Oxf) 219: 781-789, 2017. *: Co-first authors. With editorial commentary.

12. Kameshima S, Okada M, and Yamawaki H. (Review) Mechanisms of control of cardiovascular, tumorous and neuronal diseases by eEF2K/eEF2 signaling and suggestion of eEF2K/eEF2 as pharmacotherapeutic target. Folia Pharmacol Jpn 149: 194-199, 2017.

[13]. Usui T, Sakurai M, Nishikawa S, Umata K, Nemoto Y, Haraguchi T, Inamoto K, Mizuno T, Noguchi S, Mori T, Iwai S, Nakagawa T, Yamawaki H, Ohama T, and Sato K. Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells. Cancer Sci 108: 2383-2392, 2017.

[14]. Usui T, Sakurai M, Kawasaki H, Ohama T, Yamawaki H, and Sato K. Establishment of a novel three-dimensional primary culture model for hippocampal neurogenesis. Physiol Rep 5: e13318, 2017.

[15]. Kake S, Usui T, Ohama T, Yamawaki H, and Sato K. Death-associated protein kinase 3 controls tumor progression of A549 cells through ERK MAPK/c-Myc signaling. Oncol Rep 37: 1100-1106, 2017.


(2016)

1. Kameshima S, Okada M, Ikeda S, Watanabe Y, and Yamawaki HCoordination of  changes in expression and phosphorylation of  eukaryotic elongation factor 2 (eEF2) and eEF2  kinase  in hypertrophied  cardiomyocytes.  Biochem  Biophys  Reports 7: 218-224, 2016.

2. Okada M, Morioka S, Kanazawa H, and Yamawaki H. Canstatin inhibits isoproterenol-induced apoptosis through preserving mitochondrial morphology in differentiated H9c2 cardiomyoblasts. Apoptosis 21: 887-895, 2016.

3. Imoto K, Kumatani S, Okada M, and Yamawaki H. Endostatin is protective against monocrotaline-induced right heart disease through the inhibition of T-type Ca2+ channel . Pflugers Archiv - Eur J Physiol 468: 1259-1270, 2016.

4. Kameshima S, Sakamoto Y, Okada M, and Yamawaki H. Vaspin prevents elevation of blood pressure through inhibition of peripheral vascular remodeling in spontaneously hypertensive rats. Acta Physiol (Oxf) 217: 120-129, 2016.

5. Kameshima S, Okada M, and Yamawaki H. Expression and localization of calmodulin-related proteins in brain, heart and kidney from spontaneously hypertensive rats. Biochem Biophys Res Commun 469: 654-658, 2016.

6. Kameshima S*, Yamada K*, Morita T, Okada M, and Yamwaki H. Visceral adipose tissue-derived serine protease inhibitor augments acetylcholine-induced relaxation via the inhibition of acetylcholine esterase activity in rat isolated mesenteric artery. Acta Physiol (Oxf) 216: 203-210, 2016. *: Co-first authors.  With editorial commentary.

[7]. Usui T, Sakurai M, Enjoji S, Kawasaki H, Umata K, Ohama T, Fujiwara N, Yabe R, Tsuji S, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, and Sato K. Establishment of a novel model for anti-cancer drug resistance in three-dimensional primary culture of tumor microenvironment. Stem Cells Int 7053872, 2016.


(2015)

1. Okada M, and Yamawaki H. Levosimendan inhibits interleukin-1-beta-induced apoptosis through activation of Akt and inhibition of inducible nitric oxid syntahse in rat cardiac fibroblasts. Eur J Pharmacol 769: 86-92, 2015.

2. Otani K, Okada M, and Yamawaki H. Expression pattern and function of tyrosine receptor kinase B isoforms in rat mesenteric arterial smooth muscle cells. Biochem Biophys Res Commun 467: 683-689, 2015.

3. Kunimoto H, Kazama K, Takai M, Oda M, Okada M, and Yamawaki H. Chemerin promotes proliferation and migration of vascular smooth muscle and increases mouse blood pressure. Am J Physiol-Heart and Circulatory Physiology 309: H1017-H1028, 2015.

4. Yasuda J*, Takada L*, Kajiwara Y*, Okada M, and Yamawaki H. Endostatin inhibits bradykinin-induced cardiac contraction. J Vet Med Sci 77: 1391-1395, 2015.  *: Co-first authors.

5. Yasuda J, Okada M, and Yamawaki H. Endostatin inhibits T-type Ca2+ channel current in guinea pig ventricular myocyte. J Vet Med Sci 77: 1289-1291, 2015.

6. Kameshima S, Kazama K, Okada M, and Yamawaki H.  Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling. Am J Physiol-Heart and Circulatory Physiology 308: H1298-H1305, 2015.

7. Okada M, Oba Y, and Yamawaki H. Endostatin stimulates proliferation and migration of adult rat cardiac fibroblasts through PI3K/Akt pathway.  Eur J Pharmacol 750: 20-26, 2015.

8. Kazama K, Okada M, and Yamawaki H. Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species. Biochem Biophys Res Commun 457: 602-607, 2015.

9. Usui T, Nijima R, Sakatsume T, Otani K, Kameshima S, Okada M, and Yamawaki H. Eukaryotic elongation factor2 kinase controls proliferation and migration of vascular smooth muscle cells. Acta Physiol (Oxf) 213: 472-480, 2015.

10. Kazama K, Okada M, and Yamawaki H. (Review) Is novel adipocytokine, omentin, a therapeutic target for obesity-related hypertension? Folia Pharmacol Jpn 145: 65-69, 2015.

[11]. Sakai K, Yonezawa T, Yamawaki H, and Oyamada T. Alteration of somatostatin receptor 2 expression in canine mammary gland tumor. J Vet Med Sci 77: 1319-1322, 2015.


(2014)

1. Kazama K, Okada M, and Yamawaki H. A novel adipocytokine, omentin, inhibits monocrotaline-induced pulmonary arterial hypertension in rats. Biochem Biophys Res Commun 452: 142-146, 2014.

2. Usui T, Sakatsume T, Nijima R, Otani K, Kazama K, Morita T, Kameshima S, Okada M, and Yamawaki H. Death-associated protein kinase3 mediates vascular structural remodeling via stimulating smooth muscle cell proliferation and migration. Clin Sci (Lond) 127: 539-548, 2014.

3. Morita T, Okada M, and Yamawaki H. Mechanisms underlying a decrease in KCl-induced contraction after long-term serum-free organ culture of rat isolated mesenteric artery. J Vet Med Sci 76: 963-969, 2014.

4. Kazama K, Okada M, and Yamawaki H. A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through anti-oxidative mechanism. Am J Physiol-Heart and Circulatory Physiology 306: H1714-H1719, 2014.
 
5. Usui T, Naruo A, Okada M, Hayabe Y, and Yamawaki H. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells. Acta Physiol (Oxf) 211: 385-394, 2014. With Editorial commentary.

6. Usui T, Morita T, Okada M, and Yamawaki H. Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells. Hypertension 63: 397-403, 2014. 

7. Usui T, Okada M, and Yamawaki H. (Review) Zipper interacting protein kinase (ZIPK): function and signaling. Apoptosis 19: 387-391, 2014.


(2013)

1. Okada M, Suzuki A, Yamawaki H, and Hara Y. Levosimendan inhibits interleukin-1b-induced cell migration and MMP-9 secretion in rat cardiac fibroblasts. Eur J Pharmacol 718: 332-339, 2013.

2. Phalitakul S, Okada M, Hara Y, and Yamawaki H. Vaspin prevents methylglyoxal-induced apoptosis in human vascular endothelial cells by inhibiting reactive oxygen species generation. Acta Physiol (Oxf) 209: 212-219, 2013. With Editorial commentary.

3. Usui T, Okada M, Hara Y, and Yamawaki H.  Eukaryotic elongation factor 2 kinase regulates the development of hypertension through oxidative stress-dependent vascular inflammation. Am J Physiol-Heart and Circulatory Physiology 305: H756-H768, 2013. 

4. Kazama K, Okada M, Hara Y, and Yamawaki H. A novel adipocytokine, omentin, inhibits agonists-induced increases of blood pressure in rats. J Vet Med Sci 75: 1029-1034, 2013.

5. Okada M, Watanabe S, Matada T, Asao Y, Hamatani R, Yamawaki H, and Hara Y. Inhibitory Effects of Psychotropic Drugs on the Acetylcholine Receptor-Operated Potassium Current (IK.ACh) in Guinea-pig Atrial Myocytes. J Vet Med Sci 75:743-747, 2013.

6. Okada M, Noma C, Yamawaki H, and Hara Y. Negative inotropic effect of carbachol and interaction between acetylcholine receptor-operated potassium channel (K.ACh channel) and GTP binding protein in mouse isolated atrium- a novel methodological trial. J Vet Med Sci 75:377-380, 2013.

7. Mukohda M, Morita T, Okada M, Hara Y, and Yamawaki H. Long-term methylglyoxal treatment causes endothelial dysfunction of rat isolated mesenteric artery.
J Vet Med Sci 75:151-157, 2013.

8. Morita T, Okada M, Hara Y, and Yamawaki H. Addition of adult serum improves endothelium-dependent relaxation of organ-cultured rat mesenteric artery via inhibiting mitochondrial reactive oxygen species. Vascul Pharmacol 58:105-111, 2013.

9. UsuiT, Okada M, Hara Y, and Yamawaki H. (Review) Vascular effects of novel calmodulin-related proteins that mediate development of hypertension. Folia Pharmacol Jpn 141:85-89, 2013.


(2012)

1. Mukohda M, Okada M, Hara Y, and Yamawaki H.  Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in SHR. J Pharmacol Sci 120:26-35, 2012.

2. Usui T, Okada M, Hara Y, and Yamawaki H.  DAPK3 mediates vascular inflammation and development of hypertension in spontaneously hypertensive rats. Hypertension 60:1031-1039, 2012.

3. Phalitakul S, Okada M, Hara Y, and Yamawaki H. A novel adipocytokine, vaspin inhibits platelet-derived growth factor-BB-induced migration of vascular smooth muscle cells. Biochem Biophys Res Commun 423:844-849, 2012.

4.
Yamawaki H, Kameshima S, Usui T, Okada M, and Hara Y. A novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells. Biochem Biophys Res Commun 423:152-157, 2012.

5. Okada M, Mizuno W, Nakarai R, Matada T, Yamawaki H, and Hara Y. Benzodiazepines inhibit the acetylcholine receptor-operated potassium current (IK.ACh) by different mechanisms in guinea-pig atrial myocytes. J Vet Med Sci 74:879-884, 2012.
6.Kazama K, Usui T, Okada M, Hara Y, and Yamawaki H. Omentin plays an anti-inflammatory role through inhibition of TNF-a-induced superoxide production in vascular smooth muscle cells. Eur J Pharmacol 686:116-123, 2012.

7.
Usui T, Okada M, Mizuno W, Oda M, Ide N, Morita T, Hara Y, and Yamawaki H. HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. Am J Physiol-Heart and Circulatory Physiology 302:H1894-H1904, 2012.

8. Yamawaki H, Takahashi M, Mukohda M, Morita T, Okada M, and Hara Y. A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats. Biochem Biophys Res Commun 418:676-681, 2012.

9. Mukohda M, Morita T, Okada M, Hara Y, and Yamawaki H. Long-term methylglyoxal treatment impairs smooth muscle contractility in organ-cultured rat mesenteric artery. Pharmacol Res 65:91-99, 2012.


10. Mukohda M, Okada M, Hara Y, and Yamawaki H .(Review) Exploring mechanisms of diabetes-related macrovascular complications: role of methylglyoxal, a metabolite of glucose on regulation of vascular contractility. J Pharmacol Sci 118:303-310, 2012.

[11]. Iwanaga K, Okada M, Murata T, Hori M, and Ozaki H. Prostaglandin E2 promotes wound-induced migration of intestinal subepithelial myofibroblasts via EP2, EP3 and EP4 activation. J Pharmacol Exp Ther 340:604-611, 2012.

(2011)

1. Morita T, Okada M, Hara Y, and Yamawaki H. Mechanisms underlying impairment of endothelium-dependent relaxation by fetal bovine serum in organ-cultured rat mesenteric artery. Eur J Pharmacol 668:401-406, 2011. 

2. Phalitakul S, Okada M, Hara Y, and Yamawaki H. Vaspin prevents TNF-a-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-kB and PKCq activation in cultured rat vascular smooth muscle cells. Pharmacol Res 64:493-500, 2011. 

3. Yamawaki H, Kuramoto J, Kameshima S, Usui T, Okada M, and Hara Y. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Biochem Biophys Res Commun 408:339-343, 2011. 

4. Usui T, Okada M, Hara Y, and Yamawaki H. Exploring calmodulin-related proteins, which mediate development of hypertension, in vascular tissues of spontaneous hypertensive rats. Biochem Biophys Res Commun 405:47-51, 2011.

5. Yamawaki H. (Review) Vascular effects of novel adipocytokines: focus on vascular contractility and inflammatory responses. Biol Pharma Bull 34:307-310, 2011.

6. Yamawaki H. (Review) Mechanisms of action of novel adipocytokines on the vascular system. Folia Pharmacol Jpn 137: 131-135, 2011. 

[7]. Kida T, Chuma H, Murata T, Yamawaki H, Matsumoto S, Hori M, and Ozaki H. Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery. Atherosclerosis 214:288-294, 2011.


(2010)

1. Yamawaki H, Tsubaki N, Mukohda M, Okada M, and Hara Y. Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels. Biochem Biophys Res Commun. 393:668-672, 2010.

2. Mukohda M, Yamawaki H, Okada M, and Hara Y. Methylglyoxal augments angiotensin II-induced contraction in rat isolated carotid artery. J Pharmacol Sci 114:390-398, 2010. 

3. Mukohda M, Yamawaki H, Okada M, and Hara Y. Methylglyoxal enhances sodium nitroprusside-induced relaxation in rat aorta. J Pharmacol Sci 112:176-183, 2010.

4. Mukohda M, Ueno S, Kamibayashi M, Okada M, Yamawaki H, and Hara Y. Influences of organic solvents on CYPMPO-electron spin resonance spectra in in vitro radical generating systems. J Vet Med Sci 72:1547-50, 2010. 

5. Morita T, Yamawaki H, Okada M, and Hara Y. Contractile characteristics of rat mesenteric artery after organ culture. J Vet Med Sci 72:1621-7, 2010. 

6. Usui T, Yamawaki H, Kamibayashi M, Okada M, and Hara Y. Mechanisms underlying a Ca2+/calmodulin antagonist, CV-159-mediated anti-inflammatory effects in cultured vascular smooth muscle cells. J Pharmacol Sci 113:214-223, 2010. 

7. Usui T, Yamawaki H, Kamibayashi M, Okada M, and Hara Y. CV-159, a unique dihydropyridine derivative, prevents TNF-induced inflammatory responses in human umbilical vein endothelial cells. J Pharmacol Sci 113:182-191, 2010. 

8. Okada M, Yamawaki H, and Hara Y. Angiotensin II enhances interleukin-1beta-induced MMP-9 secretion in adult rat cardiac fibroblasts. J Vet Med Sci 72:735-739, 2010. 

9. Okada M, Kosaka N, Hoshino Y, Yamawaki H, and Hara Y. Effects of captopril and telmisartan on Matrix metalloproteinase-2 and -9 expressions and development of left ventricular fibrosis induced by isoprenaline in rats. Biol Pharma Bull 33:1517-1521, 2010.

 

(2009)

1. Hara Y, Ike A, Tanida R, Okada M, and Yamawaki H. Involvement of cyclooxygenase-2 in carbachol-induced positive inotropic response in mouse isolated left atrium. J Pharmacol Exp Ther 331:808-815, 2009.

2. Okada M, Harada T, Kikuzuki R, Yamawaki H, and Hara Y. Effects of telmisartan on right ventricular remodeling induced by monocrotaline in rats. J Pharmacol Sci 111:193-200, 2009.

3. Fu B-D, Yamawaki H, Okada M, and Hara Y. Vaspin can not inhibit TNF-a-induced inflammation of human umbilical vein endothelial cells. J Vet Med Sci 71:1201-1207, 2009.

4. Yamawaki H, Hara N, Okada M, and Hara Y. Visfatin causes endothelium-dependent relaxation in isolated blood vessels. Biochem Biophys Res Commun 383:503-508, 2009. 

5. Mukohda M, Yamawaki H, Nomura H, Okada M, and Hara Y. Methylglyoxal inhibits smooth muscle contraction in isolated blood vessels. J Pharmacol Sci 109:305-310, 2009. 

 

(2008)

1. Yamawaki H, Saito K, Okada M, and Hara Y. Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells. Am J Physiol Cell Physiol 295:C1510-C1517, 2008. 

2. Okada M, Kikuzuki R, Harada T, Hori Y, Yamawaki H, and Hara Y. Captopril attenuates matrix metalloproteinase-2 and -9 in monocrotaline-induced right ventricular hypertrophy in rats. J Pharmacol Sci 108:487-494, 2008. 

3. Nomura H, Yamawaki H, Mukohda M, Okada M, and Hara Y. Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel. J Pharmacol Sci 108:258-265, 2008.

4. Baden T, Yamawaki H, Saito K, Mukohda M, Okada M, and Hara Y. Telmisartan inhibits methylglyoxal-mediated cell death in human vascular endothelium. Biochem Biophys Res Commun 373:253-257, 2008. 

5. Yamawaki H, and Hara Y. Glyoxal causes inflammatory injury in human vascular endothelial cells. Biochem Biophys Res Commun 369:1155-1159, 2008. 


(受賞歴)

第33回 日本薬理学会 学術奨励賞

2017-2018年度 獣医学奨励賞

2016-2017年度 獣医学奨励賞

2015-2016年度 獣医学奨励賞

平成24年度   獣医学奨励賞

第151回日本獣医学会学術集会 大会長賞

2019年度 大村賞

平成30年度 大村賞

平成29年度 大村賞

平成28年度 大村賞

第31回 二宮善基記念賞

第17回 森村豊明会奨励賞

第7回 森村豊明会奨励賞

第162回 日本獣医学会学術集会 日本比較薬理毒性学会奨励賞

第148回 日本獣医学会学術集会 日本比較薬理毒性学会奨励賞

第155回 日本獣医学会学術集会 優秀ポスター賞

第147回 日本獣医学会学術集会 優秀ポスター賞

第145回 日本獣医学会学術集会 ベストプレゼンテーション賞

第29回 日本循環薬理学会 優秀演題賞